A SECRET WEAPON FOR PKRRATING

The interfacial residues are hugely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assistance a product where by activating RNA serves as being a scaffold to bind various PKR monomers, exp

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